Hi, This is a theoretical question, but worth a discussion. Lets say someone kisses a person with a cold sore and has virus particles transfered to the other person on the lips. How long does it take the virus to work its way into the cells and start to make copies of itself. I dont think its instantaneous, the virus probably takes sometime before it enters the cell. Also I am assuming the first copies the virus makes is probably on the outer skin layers, once an infection has been made and the immune system left offguard, some of the copied virus probably make their way to the sacral ganglion. So the whole process of viral entry and making copies should be in the span of 1 week I guess. Anyone who can shed some light?