After so much reading on this site, I am very confused by the treatment I received from my doctor. Here are the facts: Symptoms = -sores in genital area (3, he said) -extreme sciatic pain that began prior to the sores and remained Treatment = -Prednisone 50mg 1x/day for 5 days -Valtrex 1000mg 2x/day for 7 days Results = -Sciatic pain decreased completely while on Prednisone, but came back. -Sores healed My fear is that the Prednisone could have rendered the Valtrex ineffective, hence the continued sciatic pain possibly indicating continued infection? My doctor did mention Shingles as something to rule out, which could explain the Prednisone. I'm still waiting for the swab results to find out my exact diagnosis. Has anyone else been given Prednisone to assist with other symptoms during OBs?